L acidophilus La-14® is a lactic acid bacterium of human origin that has been documented in over 50 scientific studies, including 18 clinical trials. Preclinical studies have shown La-14® can impact both the innate and adaptive immune system.1,2 These effects and antipathogenic activity are thought to be potential mechanisms behind the efficacy of La-14® combined with HN001™ in women’s health.3,4 In addition, these two strains together have been shown to support healthy vaginal colonization through oral supplementation.5
LACTOBACILLUS ACIDOPHILUS
La-14®
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La-14® introduction
37 In vitro through product functionality studies
+17
Clinical trials
| HEALTH-BENEFIT AREA | SUPPORTED DOSING (CFU) | STUDY REFERENCE |
| Women’s Health (Vaginal colonization) | 10 billion La-14®, HN001™, lactoferrin | De Alberti D, et al. Arch Gynecol Obstet. 2015;292(4):861-867. |
| Women’s Health (Vaginitis/vaginosis) | 5 billion La-14®, HN001™, with 50 mg of bovine lactoferrin RCX™ | Russo R, et al. Arch Gynecol Obstet. 2018;298(1):139-145. |
| Women’s Health (Bacterial vaginosis) | 5-10 billion La-14®, HN001™, lactoferrin in patients being treated with metronidazole (500 mg twice daily) | Russo R, et al. Benef Microbes. 2019;10(1):19-26. |
| Women’s Health (Vulvovaginal candidiasis) | 5-10 billion La-14®, HN001™, lactoferrin in patients being treated with topical clotrimazole (100 mg) | Russo R, et al. Mycoses. 2018;62(4):328-335. |
For additional information, visit our La-14® bibliography
REFERENCES:
1. Elawadli I, Brisbin JT, Mallard BA, et al. Differential effects of lactobacilli on activation and maturation of mouse dendritic cells. Beneficial Microbes. 2014;5(3):323-334. 2. Paineau D, Carcano D, Leyer G. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 2008;53(1):107-113. 3. Bertuccini L, Russo R, Iosi F, Superti F. Effects of Lactobacillus rhamnosus and Lactobacillus acidophilus on bacterial vaginal pathogens. Intl J Immunopathology Pharmacology. 2017;30(2):163-167. 4. Jang SE, Jeong JJ, Choi SY, et al. Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 attenuate gardnerella vaginalis-infected bacterial vaginosis in mice. Nutrients. 2017;9:531; doi:10.3390/nu9060531. 5. De Alberti D, Russo R, Terruzzi F, Nobile V, Ouwehand AC. Lactobacilli vaginal colonisation after oral consumption of Respecta® complex: a randomized controlled pilot study. Arch Gynecol Obstet. 2015;292(4):861-867.
1. Elawadli I, Brisbin JT, Mallard BA, et al. Differential effects of lactobacilli on activation and maturation of mouse dendritic cells. Beneficial Microbes. 2014;5(3):323-334. 2. Paineau D, Carcano D, Leyer G. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol. 2008;53(1):107-113. 3. Bertuccini L, Russo R, Iosi F, Superti F. Effects of Lactobacillus rhamnosus and Lactobacillus acidophilus on bacterial vaginal pathogens. Intl J Immunopathology Pharmacology. 2017;30(2):163-167. 4. Jang SE, Jeong JJ, Choi SY, et al. Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 attenuate gardnerella vaginalis-infected bacterial vaginosis in mice. Nutrients. 2017;9:531; doi:10.3390/nu9060531. 5. De Alberti D, Russo R, Terruzzi F, Nobile V, Ouwehand AC. Lactobacilli vaginal colonisation after oral consumption of Respecta® complex: a randomized controlled pilot study. Arch Gynecol Obstet. 2015;292(4):861-867.
