Grant JR, Stothard P. The CGView Server: a comparative genomics tool for circular genomes. Nucleic Acids Res. 2008;36:W181-W184.

HN019™ introduction

B lactis HN019™ has been consumed in dairy foods for decades and is well-studied for its probiotic properties in more than 100 scientific publications.  It has been demonstrated to tolerate acidic conditions and shown to survive passage through the human intestine.1-3 Mechanistic data suggests HN019™ may influence colonic motility, and multiple clinical trials with HN019™ alone or in combination with prebiotics or other probiotic strains have resulted in increased gut transit in persons with less frequent bowel movements.4-6 HN019™ has also been shown to modulate immune function, particularly enhancing cellular immune activity in aging persons.7

62 In vitro through product functionality studies


Clinical trials

For additional information, visit our HN019™ bibliography

1. Gopal PK, Prasad J, Gill HS Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research. 2003;23:1313-1328. 2. Prasad J, Sazawal S, Dhingra U, Gopal PK Detection of viable Bifidobacterium lactis HN019 (DR10TM) in stools of children during a synbiotic dietary intervention trial. Intl Dairy J. 2013;30:64-67. 3. Wickens K, Black PN, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clinical Immunology. 2008;122:788-794. 4. Dalziel JE, Anderson RC, Peters JS, et al. Promotility action of the probiotic Bifidobacterium lactis HN019 extract compared with prucalopride in isolated rat large intestine. Frontiers in Neuroscience. 2017; 11. 5. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled and dose-ranging trial. Gut Microbes. 2017; Dec 11:0. 6. Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scandinavian J Gastroenterology. 2011;46:1057-1064. 7. Miller LE, Lehtoranta L, Lehtinen MJ. The Effect of Bifidobacterium animalis ssp. lactis HN019 on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients. 2017;9:191.
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