L. acidophilus NCFM® was first isolated from a human source in the early 1970s. NCFM® has been safely investigated in more than 330 scientific studies, including more than 60 human clinical trials as a single entity and in combination with other probiotics and prebiotics. It has been studied alongside other strains as a component of the HOWARU® Restore Blend (NCFM®, Lpc-37™, Bi-07™, Bl-04®) for digestive health and with Bi-07™ for pediatric immune health.1,2 The subjects in these trials have ranged from infants to aging populations (from 6 months to over 65 years of age). It has a long history of safe use, is well suited for intestinal survival, and has strong adhesion to intestinal cell lines.3,4
LACTOBACILLUS ACIDOPHILUS
NCFM®
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NCFM® introduction
272 In vitro through product functionality studies
+67
Clinical trials
| HEALTH-BENEFIT AREA | SUPPORTED DOSING (CFU) | STUDY REFERENCE |
| Dysbiosis restoration | 17 billion (equal parts) NCFM®, Bl-04®, Bi-07™, Lpc-37™ | Ouwehand AC, et al. Vaccine. 2014;32(4):458-463. |
| Pediatric immune health | 10 billion (equal parts) NCFM® and Bi-07™ | Leyer GJ, et al. Pediatrics. 2009;124(2):e172-179. |
For additional information, visit our NCFM® bibliography
REFERENCES:
1. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463. 2. Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172-179. 3. Andreasen AS, Larsen N, Pedersen-Skovsgaard T, et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 2010;104:1831-1838. 4. Kleeman EG, Klaenhammer TR Adherence of Lactobacillus species to human fetal intestinal cells. J Dairy Sci. 1982;65:2063-2069.
1. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463. 2. Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172-179. 3. Andreasen AS, Larsen N, Pedersen-Skovsgaard T, et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 2010;104:1831-1838. 4. Kleeman EG, Klaenhammer TR Adherence of Lactobacillus species to human fetal intestinal cells. J Dairy Sci. 1982;65:2063-2069.
