Grant JR, Stothard P. The CGView Server: a comparative genomics tool for circular genomes. Nucleic Acids Res. 2008;36:W181-W184.

Bl-04® introduction

B. lactis Bl-04® is a human isolate long considered safe and suitable for human consumption. Known for its excellent stability, Bl-04® has been present in a variety of foods and supplements for decades.  It has also been shown to survive passage through the human intestine.1,2 Bl-04® studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for Respiratory Health.3,4  With more than 20 clinical trials, Bl-04® has also been studied in combination with other strains, including NCFM®, Bi-07™, and Lpc-37™ as part of the HOWARU® Restore blend for Digestive Health.5

58 In vitro through product functionality studies


Clinical trials

Dysbiosis restoration 17 billion (equal parts) Bl-04®, NCFM®, Bi-07™, Lpc-37™ Ouwehand AC, et al. Vaccine. 2014;32(4):458-463.
Upper respiratory tract illness  2 billion Bl-04® West NP, et al. Clin Nutr. 2014;33(4):581-587.
Respiratory health 2 billion Bl-04® Turner RB, et al. Benef Microbes. 2017;8(2):207-215.

For additional information, visit our Bl-04® bibliography

1. Bartosch S, Woodmansey EJ, Paterson JC, McMurdo ME, Macfarlane GT. Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis. 2005;40:28-37. 2. Ouwehand AC, Nermes M, Collado MC, et al. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterology. 2009;15. 3. Turner R, Woodfolk J, Borish L, et al. Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection – a randomised controlled trial. Beneficial Microbes. 2017;8:207-215. 4. West NP, Horn PL, Pyne DB, et al. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr. 2014;33:581-587. 5. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463.
The information on this site is intended for healthcare professionals in the United States and is not intended for the general public.