B. lactis Bl-04® is a human isolate long considered safe and suitable for human consumption. Known for its excellent stability, Bl-04® has been present in a variety of foods and supplements for decades. It has also been shown to survive passage through the human intestine.1,2 Bl-04® studies suggest it mechanistically modulates the immune system, and clinical data supports the use of this strain for Respiratory Health.3,4 With more than 20 clinical trials, Bl-04® has also been studied in combination with other strains, including NCFM®, Bi-07™, and Lpc-37™ as part of the HOWARU® Restore blend for Digestive Health.5
BIFIDOBACTERIUM LACTIS
Bl-04®
In this section
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Bl-04® introduction
58 In vitro through product functionality studies
+21
Clinical trials
| HEALTH-BENEFIT AREA | SUPPORTED DOSING (CFU) | STUDY REFERENCE |
| Dysbiosis restoration | 17 billion (equal parts) Bl-04®, NCFM®, Bi-07™, Lpc-37™ | Ouwehand AC, et al. Vaccine. 2014;32(4):458-463. |
| Upper respiratory tract illness | 2 billion Bl-04® | West NP, et al. Clin Nutr. 2014;33(4):581-587. |
| Respiratory health | 2 billion Bl-04® | Turner RB, et al. Benef Microbes. 2017;8(2):207-215. |
For additional information, visit our Bl-04® bibliography
REFERENCES:
1. Bartosch S, Woodmansey EJ, Paterson JC, McMurdo ME, Macfarlane GT. Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis. 2005;40:28-37. 2. Ouwehand AC, Nermes M, Collado MC, et al. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterology. 2009;15. 3. Turner R, Woodfolk J, Borish L, et al. Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection – a randomised controlled trial. Beneficial Microbes. 2017;8:207-215. 4. West NP, Horn PL, Pyne DB, et al. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr. 2014;33:581-587. 5. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463.
1. Bartosch S, Woodmansey EJ, Paterson JC, McMurdo ME, Macfarlane GT. Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis. 2005;40:28-37. 2. Ouwehand AC, Nermes M, Collado MC, et al. Specific probiotics alleviate allergic rhinitis during the birch pollen season. World J Gastroenterology. 2009;15. 3. Turner R, Woodfolk J, Borish L, et al. Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection – a randomised controlled trial. Beneficial Microbes. 2017;8:207-215. 4. West NP, Horn PL, Pyne DB, et al. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr. 2014;33:581-587. 5. Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine. 2014;32:458-463.
