Our meticulous and thorough HOWARU® VERIFY protocol makes HOWARU® probiotics unlike many other options. From genetic screening to FDA acceptance, HOWARU® strains are subject to unique quality and safety evaluations.

Strain identification 

The complete genome of each HOWARU® strain has been sequenced and fully assembled to properly classify to the genus, species, and strain. Stringent process controls are maintained to ensure the commercial strain is identical to the studied strain.

Genetic safety screening 

HOWARU® strains are tested for virulence and toxigenic properties and the absence of antibiotic resistance transfer potential as a fundamental safety requirement established by regulatory bodies (eg, European Food Safety Authority, Health Canada, Therapeutic Goods Administration [Australia]).

Toxicity testing 

HOWARU® strains undergo toxicity testing to confirm safety for human consumption. 

Stability assurance

HOWARU® strains are formulated for and evaluated in multiple formats and across various temperature and humidity conditions to ensure viability through end of shelf life.

Survivability

HOWARU® strains are tested for tolerance to stomach acid and bile salts.

Quality auditing

HOWARU® strains are consistently manufactured in the USA in either Madison, WI, or Rochester, NY, under FDA Good Manufacturing Practices. Quality systems are audited regularly by the National Science Foundation (NSF) to maintain NSF dietary supplement certification. 

FDA evaluated

HOWARU® probiotic strains are Generally Recognized as Safe (GRAS) and have been notified to the FDA and accepted with no objection.

Clinical testing

Each HOWARU® probiotic strain has been clinically tested to demonstrate efficacy.